Assessment of the relationship between genotypic status of a DT-diaphorase point mutation and enzymatic activity

DT-diaphorase, a cytosolic reductase, has been implicated as an activator of chemotherapeutic prodrugs and a detoxifier of certain potentially carcinogenic xenobiotics. A common C to T nucleotide 609 substitution in DT-diaphorase cDNA has been associated with protein instability and reduced catalyti...

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Detalles Bibliográficos
Autores principales: Misra, V, Grondin, A, Klamut, H J, Rauth, A M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363567/
https://www.ncbi.nlm.nih.gov/pubmed/10993645
http://dx.doi.org/10.1054/bjoc.2000.1359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363567/
https://www.ncbi.nlm.nih.gov/pubmed/10993645
http://dx.doi.org/10.1054/bjoc.2000.1359

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