Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro

The potent novel poly(ADP-ribose) polymerase (PARP) inhibitor, NU1025, enhances the cytotoxicity of DNA-methylating agents and ionizing radiation by inhibiting DNA repair. We report here an investigation of the role of PARP in the cellular responses to inhibitors of topoisomerase I and II using NU10...

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Detalles Bibliográficos
Autores principales: Bowman, K J, Newell, D R, Calvert, A H, Curtin, N J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363607/
https://www.ncbi.nlm.nih.gov/pubmed/11139322
http://dx.doi.org/10.1054/bjoc.2000.1555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363607/
https://www.ncbi.nlm.nih.gov/pubmed/11139322
http://dx.doi.org/10.1054/bjoc.2000.1555

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