Selective cancer cell killing by α-tocopheryl succinate

We report that α-tocopheryl succinate, a vitamin E analogue with pro-apoptotic properties, selectively kills cells with a malignant or transformed phenotype, i.e. multiple haematopoietic and carcinoma cell lines, while being non-toxic to normal, i.e. primary and non-transformed cells. These findings...

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Detalles Bibliográficos
Autores principales: Neuzil, J, Weber, T, Gellert, N, Weber, C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363620/
https://www.ncbi.nlm.nih.gov/pubmed/11139318
http://dx.doi.org/10.1054/bjoc.2000.1559
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author Neuzil, J
Weber, T
Gellert, N
Weber, C
author_facet Neuzil, J
Weber, T
Gellert, N
Weber, C
author_sort Neuzil, J
collection PubMed
description We report that α-tocopheryl succinate, a vitamin E analogue with pro-apoptotic properties, selectively kills cells with a malignant or transformed phenotype, i.e. multiple haematopoietic and carcinoma cell lines, while being non-toxic to normal, i.e. primary and non-transformed cells. These findings strongly suggest a potential of this micronutrient in the therapy and/or prevention of cancer without significant side-effects. © 2001 Cancer Research Campaign http://www.bjcancer.com
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spelling pubmed-23636202009-09-10 Selective cancer cell killing by α-tocopheryl succinate Neuzil, J Weber, T Gellert, N Weber, C Br J Cancer Short Communication We report that α-tocopheryl succinate, a vitamin E analogue with pro-apoptotic properties, selectively kills cells with a malignant or transformed phenotype, i.e. multiple haematopoietic and carcinoma cell lines, while being non-toxic to normal, i.e. primary and non-transformed cells. These findings strongly suggest a potential of this micronutrient in the therapy and/or prevention of cancer without significant side-effects. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-01 2001-01-01 /pmc/articles/PMC2363620/ /pubmed/11139318 http://dx.doi.org/10.1054/bjoc.2000.1559 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Neuzil, J
Weber, T
Gellert, N
Weber, C
Selective cancer cell killing by α-tocopheryl succinate
title Selective cancer cell killing by α-tocopheryl succinate
title_full Selective cancer cell killing by α-tocopheryl succinate
title_fullStr Selective cancer cell killing by α-tocopheryl succinate
title_full_unstemmed Selective cancer cell killing by α-tocopheryl succinate
title_short Selective cancer cell killing by α-tocopheryl succinate
title_sort selective cancer cell killing by α-tocopheryl succinate
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363620/
https://www.ncbi.nlm.nih.gov/pubmed/11139318
http://dx.doi.org/10.1054/bjoc.2000.1559
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AT weberc selectivecancercellkillingbyatocopherylsuccinate

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