Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients

Oral bioavailability of paclitaxel is very low, which is due to efficient transport of the drug by the intestinal drug efflux pump P-glycoprotein (P-gp). We have recently demonstrated that the oral bioavailability of paclitaxel can be increased at least 7-fold by co-administration of the P-gp blocke...

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Detalles Bibliográficos
Autores principales: Malingré, M M, Beijnen, J H, Rosing, H, Koopman, F J, Jewell, R C, Paul, E M, Huinink, W W Ten Bokkel, Schellens, J H M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363627/
https://www.ncbi.nlm.nih.gov/pubmed/11139311
http://dx.doi.org/10.1054/bjoc.2000.1543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363627/
https://www.ncbi.nlm.nih.gov/pubmed/11139311
http://dx.doi.org/10.1054/bjoc.2000.1543

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