Inhibition of protein farnesylation enhances the chemotherapeutic efficacy of the novel geranylgeranyltransferase inhibitor BAL9611 in human colon cancer cells

Proteins belonging to the ras superfamily are involved in cell proliferation of normal and neoplastic tissues. To be biologically active, they require post-translational isoprenylation by farnesyl-transferase and geranylgeranyl-transferase. Enzyme inhibition by drugs may thus represent a promising a...

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Detalles Bibliográficos
Autores principales: Paolo, A Di, Danesi, R, Caputo, S, Macchia, M, Lastella, M, Boggi, U, Mosca, F, Marchetti, A, Tacca, M Del
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363657/
https://www.ncbi.nlm.nih.gov/pubmed/11384105
http://dx.doi.org/10.1054/bjoc.2001.1820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363657/
https://www.ncbi.nlm.nih.gov/pubmed/11384105
http://dx.doi.org/10.1054/bjoc.2001.1820

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