Decrease in drug accumulation and in tumour aggressiveness marker expression in a fenretinide-induced resistant ovarianumour cell line

We investigated whether the efficacy of fenretinide (HPR) against ovarian tumours may be limited by induction of resistance. The human ovarian carcinoma cell line A2780, which is sensitive to a pharmacologically achievable HPR concentration (IC (50)= 1 μM), became 10-fold more resistant after exposu...

Descripción completa

Detalles Bibliográficos
Autores principales: Appierto, V, Cavadini, E, Pergolizzi, R, Cleris, L, Lotan, R, Canevari, S, Formelli, F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363672/
https://www.ncbi.nlm.nih.gov/pubmed/11384104
http://dx.doi.org/10.1054/bjoc.2001.1826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363672/
https://www.ncbi.nlm.nih.gov/pubmed/11384104
http://dx.doi.org/10.1054/bjoc.2001.1826

Ejemplares similares