A novel doxorubicin-glucuronide prodrug DOX-GA3 for tumour-selective chemotherapy: distribution and efficacy in experimental human ovarian cancer

The doxorubicin (DOX) prodrug N -[4-doxorubicin- N -carbonyl (oxymethyl) phenyl] O -β-glucuronyl carbamate (DOX-GA3) was synthesised for specific activation by human β-glucuronidase, which is released in necrotic areas of tumour lesions. This novel prodrug was completely activated to the parent drug...

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Detalles Bibliográficos
Autores principales: Houba, P H J, Boven, E, Meulen-Muileman, I H van der, Leenders, R G G, Scheeren, J W, Pinedo, H M, Haisma, H J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363760/
https://www.ncbi.nlm.nih.gov/pubmed/11207053
http://dx.doi.org/10.1054/bjoc.2000.1640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363760/
https://www.ncbi.nlm.nih.gov/pubmed/11207053
http://dx.doi.org/10.1054/bjoc.2000.1640

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