Lycobetaine acts as a selective topoisomerase IIβ poison and inhibits the growth of human tumour cells

The phenanthridine alkaloid lycobetaine is a minor constituent of Amaryllidaceae. Inhibition of cell growth was studied in the clonogenic assay on 21 human tumour xenografts (mean IC (50) = 0.8 μM). The growth of human leukaemia cell lines was also potently inhibited (mean IC (50) = 1.3 μM). Athymic...

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Detalles Bibliográficos
Autores principales: Barthelmes, H U, Niederberger, E, Roth, T, Schulte, K, Tang, W C, Boege, F, Fiebig, H-H, Eisenbrand, G, Marko, D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363954/
https://www.ncbi.nlm.nih.gov/pubmed/11720449
http://dx.doi.org/10.1054/bjoc.2001.2142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363954/
https://www.ncbi.nlm.nih.gov/pubmed/11720449
http://dx.doi.org/10.1054/bjoc.2001.2142

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