High levels of the MDM2 oncogene in paediatric rhabdomyosarcoma cell lines may confer multidrug resistance

The MDM2 protein is known to be overexpressed in some sarcomas including rhabdomyosarcoma. However, the extent to which the MDM2 protein influences sensitivity to chemotherapeutic drugs is unclear. We have analysed this further using stable transfection of the mdm2 gene into 4 well-characterised hum...

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Detalles Bibliográficos
Autores principales: Cocker, H A, Hobbs, S M, Tiffin, N, Pritchard-Jones, K, Pinkerton, C R, Kelland, L R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363993/
https://www.ncbi.nlm.nih.gov/pubmed/11742497
http://dx.doi.org/10.1054/bjoc.2001.2145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363993/
https://www.ncbi.nlm.nih.gov/pubmed/11742497
http://dx.doi.org/10.1054/bjoc.2001.2145

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