Cargando…

Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells

Novel synthetic antagonists of retinoic acid receptors (RARs) have been developed. To avoid interference by serum retinoids when testing these compounds, we established serum-free grown sub-lines (>3 years) of the prostate carcinoma lines LNCaP, PC3 and DU145. A high affinity pan-RAR antagonist (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hammond, L A, Krinks, C H Van, Durham, J, Tomkins, S E, Burnett, R D, Jones, E L, Chandraratna, R A S, Brown, G
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2001
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364081/ https://www.ncbi.nlm.nih.gov/pubmed/11487280 http://dx.doi.org/10.1054/bjoc.2001.1939

Ejemplares similares

An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium
por: Keedwell, R G, et al.
Publicado: (2004)

Developmental expression of retinoic acid receptors (RARs)
por: Dollé, Pascal
Publicado: (2009)

Requirement for RAR-mediated gene repression in skeletal progenitor differentiation
por: Weston, Andrea D., et al.
Publicado: (2002)

Conditional RARα knockout mice reveal acute requirement for retinoic acid and RARα in homeostatic plasticity
por: Sarti, Federica, et al.
Publicado: (2012)

Control of Innate and Adaptive Lymphocytes by the RAR-Retinoic Acid Axis
por: Kim, Chang H.
Publicado: (2018)

An Orthologue of the Retinoic Acid Receptor (RAR) Is Present in the Ecdysozoa Phylum Priapulida
por: Fonseca, Elza S. S., et al.
Publicado: (2019)

FMRP Interacts with RARα in Synaptic Retinoic Acid Signaling and Homeostatic Synaptic Plasticity
por: Park, Esther, et al.
Publicado: (2021)

Potent Inhibition of Heterotopic Ossification by Nuclear Retinoic Acid Receptor γ Agonists
por: Shimono, Kengo, et al.
Publicado: (2011)

RARα2 and PML-RAR similarities in the control of basal and retinoic acid induced myeloid maturation of acute myeloid leukemia cells
por: Gianni, Maurizio, et al.
Publicado: (2016)

Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs)
por: Rochette-Egly, Cécile, et al.
Publicado: (2009)

PTGDR expression is upregulated through retinoic acid receptors (RAR) mechanism in allergy
por: García-Sánchez, Asunción, et al.
Publicado: (2019)

All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia
por: Nguyen, Chi Huu, et al.
Publicado: (2019)

Differential and antagonistic effects of 9- cis -retinoic acid and vitamin D analogues on pancreatic cancer cells in vitro
por: Pettersson, F, et al.
Publicado: (2000)

Structural basis for DNA recognition and allosteric control of the retinoic acid receptors RAR–RXR
por: Osz, Judit, et al.
Publicado: (2020)

Molecular Characterization of Retinoic Acid Receptor CgRAR in Pacific Oyster (Crassostrea gigas)
por: Jin, Kaidi, et al.
Publicado: (2021)

Activation of the CRABPII/RAR pathway by curcumin induces retinoic acid mediated apoptosis in retinoic acid resistant breast cancer cells
por: Thulasiraman, Padmamalini, et al.
Publicado: (2017)

Retinoic acid and RARγ maintain satellite cell quiescence through regulation of translation initiation
por: Luo, Wenzhe, et al.
Publicado: (2022)

Reduced Retinoic Acid Receptor Beta (Rarβ) Affects Pancreatic β-Cell Physiology
por: Khalique, Anila, et al.
Publicado: (2022)

Modulation of docetaxel-induced apoptosis and cell cycle arrest by all- trans retinoic acid in prostate cancer cells
por: Nehmé, A, et al.
Publicado: (2001)

Decay in Retinoic Acid Signaling in Varied Models of Alzheimer’s Disease and In-Vitro Test of Novel Retinoic Acid Receptor Ligands (RAR-Ms) to Regulate Protective Genes
por: Khatib, Thabat, et al.
Publicado: (2020)

Expression of Retinoic Acid Receptor (RAR) α Protein in the Synovial Membrane from Patients with Osteoarthritis and Rheumatoid Arthritis
por: A, Zisakis, et al.
Publicado: (2007)

Improved Atrial Differentiation of Human Pluripotent Stem Cells by Activation of Retinoic Acid Receptor Alpha (RARα)
por: Schwach, Verena, et al.
Publicado: (2022)

Association analysis of retinoic acid receptor beta (RARβ) gene with high myopia in Chinese subjects
por: Ding, Yang, et al.
Publicado: (2010)

Retinoic Acid Receptor Alpha (RARα) in Macrophages Protects from Diet-Induced Atherosclerosis in Mice
por: Cassim Bawa, Fathima N., et al.
Publicado: (2022)

The Association of Retinoic Acid Receptor Beta2(RARβ2) Methylation Status and Prostate Cancer Risk: A Systematic Review and Meta-Analysis
por: Gao, Tianyi, et al.
Publicado: (2013)

Loss of growth inhibitory effects of retinoic acid in human breast cancer cells following long-term exposure to retinoic acid
por: Stephen, R, et al.
Publicado: (2000)

Anti-PML-RARα shRNA sensitises promyelocytic leukaemia cells to all-trans retinoic acid
por: Casey, Nicholas P, et al.
Publicado: (2012)

Distinct retinoic acid receptor (RAR) isotypes control differentiation of embryonal carcinoma cells to dopaminergic or striatopallidal medium spiny neurons
por: Podleśny-Drabiniok, Anna, et al.
Publicado: (2017)

Plasma membrane expression of GnRH receptors: regulation by antagonists in breast, prostate, and gonadotrope cell lines
por: Finch, Ann R, et al.
Publicado: (2008)

Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis
por: Bosch, Almudena, et al.
Publicado: (2012)

Detection of Promyelocytic Leukemia/Retinoic Acid Receptor α (PML/RARα) Fusion Gene with Functionalized Graphene Oxide
por: Li, Ran, et al.
Publicado: (2013)

Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression
por: Centritto, Floriana, et al.
Publicado: (2015)

Regulation of Retinoid-Mediated Signaling Involved in Skin Homeostasis by RAR and RXR Agonists/Antagonists in Mouse Skin
por: Gericke, Janine, et al.
Publicado: (2013)

Targeting RARA overexpression with tamibarotene, a potent and selective RARα agonist, is a novel approach in AML
por: de Botton, Stéphane, et al.
Publicado: (2022)

Is RARS-T a new disease entity or a subtype of RARS or ET?
por: Bang, Soo-Mee
Publicado: (2010)

Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations
por: le Maire, Albane, et al.
Publicado: (2019)

Switch from antagonist to agonist of the androgen receptor blocker bicalutamide is associated with prostate tumour progression in a new model system
por: Culig, Z, et al.
Publicado: (1999)

Energy status regulates levels of the RAR/RXR ligand 9-cis-retinoic acid in mammalian tissues: Glucose reduces its synthesis in β-cells
por: Yoo, Hong Sik, et al.
Publicado: (2023)

Novel therapeutic approach: organic arsenical (melarsoprol) alone or with all-trans -retinoic acid markedly inhibit growth of human breast and prostate cancer cells in vitro and in vivo
por: Koshiuka, K, et al.
Publicado: (2000)

A Phase 1 Study of IRX195183, a RARα-Selective CYP26 Resistant Retinoid, in Patients With Relapsed or Refractory AML
por: Ambinder, Alexander J., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_l4up4a7f0qu8in1jaiq7v30sq2