A common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families

One of the most common melanoma-related CDKN2A mutations reported in North America is the V126D mutation. We examined nine markers surrounding CDKN2A in three American and four Canadian families carrying the V126D mutation. All seven families had a haplotype consistent with a common ancestor/founder...

Descripción completa

Detalles Bibliográficos
Autores principales: Goldstein, A M, Liu, L, Shennan, M G, Hogg, D, Tucker, M A, Struewing, J P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364106/
https://www.ncbi.nlm.nih.gov/pubmed/11506491
http://dx.doi.org/10.1054/bjoc.2001.1944
_version_ 1782153871065350144
author Goldstein, A M
Liu, L
Shennan, M G
Hogg, D
Tucker, M A
Struewing, J P
author_facet Goldstein, A M
Liu, L
Shennan, M G
Hogg, D
Tucker, M A
Struewing, J P
author_sort Goldstein, A M
collection PubMed
description One of the most common melanoma-related CDKN2A mutations reported in North America is the V126D mutation. We examined nine markers surrounding CDKN2A in three American and four Canadian families carrying the V126D mutation. All seven families had a haplotype consistent with a common ancestor/founder for this mutation. In addition, the mutation appears to have originated 34–52 generations ago (1-LOD-unit support interval 13–98 generations). © 2001 Cancer Research Campaign http:///www.bjcancer.com
format Text
id pubmed-2364106
institution National Center for Biotechnology Information
language English
publishDate 2001
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23641062009-09-10 A common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families Goldstein, A M Liu, L Shennan, M G Hogg, D Tucker, M A Struewing, J P Br J Cancer Regular Article One of the most common melanoma-related CDKN2A mutations reported in North America is the V126D mutation. We examined nine markers surrounding CDKN2A in three American and four Canadian families carrying the V126D mutation. All seven families had a haplotype consistent with a common ancestor/founder for this mutation. In addition, the mutation appears to have originated 34–52 generations ago (1-LOD-unit support interval 13–98 generations). © 2001 Cancer Research Campaign http:///www.bjcancer.com Nature Publishing Group 2001-08 /pmc/articles/PMC2364106/ /pubmed/11506491 http://dx.doi.org/10.1054/bjoc.2001.1944 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Goldstein, A M
Liu, L
Shennan, M G
Hogg, D
Tucker, M A
Struewing, J P
A common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families
title A common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families
title_full A common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families
title_fullStr A common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families
title_full_unstemmed A common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families
title_short A common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families
title_sort common founder for the v126d cdkn2a mutation in seven north american melanoma-prone families
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364106/
https://www.ncbi.nlm.nih.gov/pubmed/11506491
http://dx.doi.org/10.1054/bjoc.2001.1944
work_keys_str_mv AT goldsteinam acommonfounderforthev126dcdkn2amutationinsevennorthamericanmelanomapronefamilies
AT liul acommonfounderforthev126dcdkn2amutationinsevennorthamericanmelanomapronefamilies
AT shennanmg acommonfounderforthev126dcdkn2amutationinsevennorthamericanmelanomapronefamilies
AT hoggd acommonfounderforthev126dcdkn2amutationinsevennorthamericanmelanomapronefamilies
AT tuckerma acommonfounderforthev126dcdkn2amutationinsevennorthamericanmelanomapronefamilies
AT struewingjp acommonfounderforthev126dcdkn2amutationinsevennorthamericanmelanomapronefamilies
AT goldsteinam commonfounderforthev126dcdkn2amutationinsevennorthamericanmelanomapronefamilies
AT liul commonfounderforthev126dcdkn2amutationinsevennorthamericanmelanomapronefamilies
AT shennanmg commonfounderforthev126dcdkn2amutationinsevennorthamericanmelanomapronefamilies
AT hoggd commonfounderforthev126dcdkn2amutationinsevennorthamericanmelanomapronefamilies
AT tuckerma commonfounderforthev126dcdkn2amutationinsevennorthamericanmelanomapronefamilies
AT struewingjp commonfounderforthev126dcdkn2amutationinsevennorthamericanmelanomapronefamilies

Ejemplares similares