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Enhanced etoposide sensitivity following adenovirus-mediated human topoisomerase II α gene transfer is independent of topoisomerase II β

The roles that the α and β isoforms of topoisomerase II (topo II) play in anticancer drug action were determined using MDA-VP etoposide-resistant human breast cancer cells and a newly constructed adenoviral vector containing the topo IIα gene (Ad-topo IIα). MDA-VP cells were more resistant to etopos...

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Detalles Bibliográficos
Autores principales:	Zhou, Z, Zwelling, L A, Ganapathi, R, Kleinerman, E S
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2001
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364113/ https://www.ncbi.nlm.nih.gov/pubmed/11531262 http://dx.doi.org/10.1054/bjoc.2001.1966

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