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Circadian optimisation of irinotecan and oxaliplatin efficacy in mice with Glasgow osteosarcoma
The relevance of circadian rhythms in irinotecan and oxaliplatin tolerability was investigated with regard to antitumour activity. Mice bearing Glasgow osteosarcoma (GOS) received single agent irinotecan (50 or 60 mg kg(−1) per day) or oxaliplatin (4 or 5.25 mg kg(−1) per day) at one of six dosing t...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2002
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364142/ https://www.ncbi.nlm.nih.gov/pubmed/11953836 http://dx.doi.org/10.1038/sj.bjc.6600168 |