Abrogation of the radiation-induced G2 checkpoint by the staurosporine derivative UCN-01 is associated with radiosensitisation in a subset of colorectal tumour cell lines

Ionising radiation is commonly used in the treatment of colorectal cancer. Tumour cells with mutant p53 undergo cell cycle arrest at G2/M after ionising radiation and evidence suggests that abrogation of this G2 arrest can lead to a premature, aberrant mitosis, thus enhancing ionising radiation-indu...

Descripción completa

Detalles Bibliográficos
Autores principales: Playle, L C, Hicks, D J, Qualtrough, D, Paraskeva, C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364214/
https://www.ncbi.nlm.nih.gov/pubmed/12177808
http://dx.doi.org/10.1038/sj.bjc.6600492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364214/
https://www.ncbi.nlm.nih.gov/pubmed/12177808
http://dx.doi.org/10.1038/sj.bjc.6600492

Ejemplares similares