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Use of radiolabelled choline as a pharmacodynamic marker for the signal transduction inhibitor geldanamycin
There is an urgent need to develop non-invasive pharmacodynamic endpoints for the evaluation of new molecular therapeutics that inhibit signal transduction. We hypothesised that, when labelled appropriately, changes in choline kinetics could be used to assess geldanamycin pharmacodynamics, which inv...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2002
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364261/ https://www.ncbi.nlm.nih.gov/pubmed/12232764 http://dx.doi.org/10.1038/sj.bjc.6600558 |