Reduced risk of synovial sarcoma in females: X-chromosome inactivation?

Synovial sarcoma shows a characteristic t(X;18) translocation but not the expected female predominance in incidence. We speculate that, among females, one X-chromosome is inactivated and that only the translocation to an active X-chromosome leads to development of synovial sarcoma. Population-based...

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Detalles Bibliográficos
Autores principales: Bu, X, Bernstein, L, Brynes, R K
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364289/
https://www.ncbi.nlm.nih.gov/pubmed/12085251
http://dx.doi.org/10.1038/sj.bjc.6600362
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author Bu, X
Bernstein, L
Brynes, R K
author_facet Bu, X
Bernstein, L
Brynes, R K
author_sort Bu, X
collection PubMed
description Synovial sarcoma shows a characteristic t(X;18) translocation but not the expected female predominance in incidence. We speculate that, among females, one X-chromosome is inactivated and that only the translocation to an active X-chromosome leads to development of synovial sarcoma. Population-based cancer registry data from the SEER program support this hypothesis. British Journal of Cancer (2002) 87, 28–30. doi:10.1038/sj.bjc.6600362 www.bjcancer.com © 2002 Cancer Research UK
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spelling pubmed-23642892009-09-10 Reduced risk of synovial sarcoma in females: X-chromosome inactivation? Bu, X Bernstein, L Brynes, R K Br J Cancer Epidemiology Synovial sarcoma shows a characteristic t(X;18) translocation but not the expected female predominance in incidence. We speculate that, among females, one X-chromosome is inactivated and that only the translocation to an active X-chromosome leads to development of synovial sarcoma. Population-based cancer registry data from the SEER program support this hypothesis. British Journal of Cancer (2002) 87, 28–30. doi:10.1038/sj.bjc.6600362 www.bjcancer.com © 2002 Cancer Research UK Nature Publishing Group 2002-07-01 2002-07-15 /pmc/articles/PMC2364289/ /pubmed/12085251 http://dx.doi.org/10.1038/sj.bjc.6600362 Text en Copyright © 2002 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Bu, X
Bernstein, L
Brynes, R K
Reduced risk of synovial sarcoma in females: X-chromosome inactivation?
title Reduced risk of synovial sarcoma in females: X-chromosome inactivation?
title_full Reduced risk of synovial sarcoma in females: X-chromosome inactivation?
title_fullStr Reduced risk of synovial sarcoma in females: X-chromosome inactivation?
title_full_unstemmed Reduced risk of synovial sarcoma in females: X-chromosome inactivation?
title_short Reduced risk of synovial sarcoma in females: X-chromosome inactivation?
title_sort reduced risk of synovial sarcoma in females: x-chromosome inactivation?
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364289/
https://www.ncbi.nlm.nih.gov/pubmed/12085251
http://dx.doi.org/10.1038/sj.bjc.6600362
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