Increased sensitivity of p53-deficient cells to anticancer agents due to loss of Pms2

A large fraction of human tumours carries mutations in the p53 gene. p53 plays a central role in controlling cell cycle checkpoint regulation, DNA repair, transcription, and apoptosis upon genotoxic stress. Lack of p53 function impairs these cellular processes, and this may be the basis of resistanc...

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Detalles Bibliográficos
Autores principales: Fedier, A, Ruefenacht, U B, Schwarz, V A, Haller, U, Fink, D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2002
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364320/
https://www.ncbi.nlm.nih.gov/pubmed/12434296
http://dx.doi.org/10.1038/sj.bjc.6600599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364320/
https://www.ncbi.nlm.nih.gov/pubmed/12434296
http://dx.doi.org/10.1038/sj.bjc.6600599

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