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Increased sensitivity of p53-deficient cells to anticancer agents due to loss of Pms2
A large fraction of human tumours carries mutations in the p53 gene. p53 plays a central role in controlling cell cycle checkpoint regulation, DNA repair, transcription, and apoptosis upon genotoxic stress. Lack of p53 function impairs these cellular processes, and this may be the basis of resistanc...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2002
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364320/ https://www.ncbi.nlm.nih.gov/pubmed/12434296 http://dx.doi.org/10.1038/sj.bjc.6600599 |