Heterologous Protein Expression Is Enhanced by Harmonizing the Codon Usage Frequencies of the Target Gene with those of the Expression Host

Synonymous codon replacement can change protein structure and function, indicating that protein structure depends on DNA sequence. During heterologous protein expression, low expression or formation of insoluble aggregates may be attributable to differences in synonymous codon usage between expressi...

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Detalles Bibliográficos
Autores principales: Angov, Evelina, Hillier, Collette J., Kincaid, Randall L., Lyon, Jeffrey A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364656/
https://www.ncbi.nlm.nih.gov/pubmed/18478103
http://dx.doi.org/10.1371/journal.pone.0002189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364656/
https://www.ncbi.nlm.nih.gov/pubmed/18478103
http://dx.doi.org/10.1371/journal.pone.0002189

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