Cargando…

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

Autophagy is a membrane-mediated intracellular degradation system. The serine/threonine kinase Atg1 plays an essential role in autophagosome formation. However, the role of the mammalian Atg1 homologues UNC-51–like kinase (ULK) 1 and 2 are not yet well understood. We found that murine ULK1 and 2 loc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hara, Taichi, Takamura, Akito, Kishi, Chieko, Iemura, Shun-ichiro, Natsume, Tohru, Guan, Jun-Lin, Mizushima, Noboru
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364687/ https://www.ncbi.nlm.nih.gov/pubmed/18443221 http://dx.doi.org/10.1083/jcb.200712064

Ejemplares similares

FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates
por: Turco, Eleonora, et al.
Publicado: (2019)

ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer
por: Shi, Xiaoshan, et al.
Publicado: (2020)

The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17
por: Jiang, Peidu, et al.
Publicado: (2014)

Interaction Between FIP200 and ATG16L1 Distinguishes ULK1 Complex-Dependent and -Independent Autophagy
por: Gammoh, Noor, et al.
Publicado: (2012)

The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment
por: Shi, Xiaoshan, et al.
Publicado: (2020)

FIP200 is required for maintenance and differentiation of postnatal neural stem cells
por: Wang, Chenran, et al.
Publicado: (2013)

ER-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of ULK1 and ULK2 Kinases
por: Anwar, Tahira, et al.
Publicado: (2019)

Suppression of Pyk2 Kinase and Cellular Activities by Fip200
por: Ueda, Hiroki, et al.
Publicado: (2000)

Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets
por: Velikkakath, Anoop Kumar G., et al.
Publicado: (2012)

p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding
por: Itakura, Eisuke, et al.
Publicado: (2011)

The COP1 E3-ligase interacts with FIP200, a key regulator of mammalian autophagy
por: Kobayashi, Saori, et al.
Publicado: (2013)

AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms
por: Nwadike, Chinwendu, et al.
Publicado: (2018)

Autophagosome maturation stymied by SARS-CoV-2
por: Yim, Willa Wen-You, et al.
Publicado: (2021)

Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17
por: Matsui, Takahide, et al.
Publicado: (2018)

Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy
por: Wang, Chenyao, et al.
Publicado: (2018)

TFG binds LC3C to regulate ULK1 localization and autophagosome formation
por: Carinci, Marianna, et al.
Publicado: (2021)

WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway
por: Goto, Toshiyasu, et al.
Publicado: (2016)

TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes
por: Longatti, Andrea, et al.
Publicado: (2012)

FIP200 restricts RNA virus infection by facilitating RIG-I activation
por: Wang, Lingyan, et al.
Publicado: (2021)

Dynamic Regulation of Ero1α and Peroxiredoxin 4 Localization in the Secretory Pathway
por: Kakihana, Taichi, et al.
Publicado: (2013)

Aberrant autophagosome formation occurs upon small molecule inhibition of ULK1 kinase activity
por: Zachari, Maria, et al.
Publicado: (2020)

Modeling Membrane Morphological Change during Autophagosome Formation
por: Sakai, Yuji, et al.
Publicado: (2020)

The mammalian ULK1 complex and autophagy initiation
por: Zachari, Maria, et al.
Publicado: (2017)

Initial Steps in Mammalian Autophagosome Biogenesis
por: Grasso, Daniel, et al.
Publicado: (2018)

MERIT40-dependent recruitment of tankyrase to damaged DNA and its implication for cell sensitivity to DNA-damaging anticancer drugs
por: Okamoto, Keiji, et al.
Publicado: (2018)

Autophagy gene FIP200 in neural progenitors non–cell autonomously controls differentiation by regulating microglia
por: Wang, Chenran, et al.
Publicado: (2017)

Regulation of immune checkpoint blockade efficacy in breast cancer by FIP200: A canonical-autophagy-independent function
por: Yeo, Syn Kok, et al.
Publicado: (2020)

A molecular perspective of mammalian autophagosome biogenesis
por: Mercer, Thomas J., et al.
Publicado: (2018)

VCP Is an Integral Component of a Novel Feedback Mechanism that Controls Intracellular Localization of Catalase and H(2)O(2) Levels
por: Murakami, Katsuhiro, et al.
Publicado: (2013)

Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases
por: Araki, Kazutaka, et al.
Publicado: (2013)

Nuclear export of ubiquitinated proteins via the UBIN-POST system
por: Hirayama, Shoshiro, et al.
Publicado: (2018)

Identification of FIP200 interaction with the TSC1–TSC2 complex and its role in regulation of cell size control
por: Gan, Boyi, et al.
Publicado: (2005)

FIP200 is Involved in Murine Pseudomonas Infection by Regulating HMGB1 Intracellular Translocation
por: Li, Yi, et al.
Publicado: (2014)

Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy
por: Ohnstad, Amelia E, et al.
Publicado: (2020)

Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3 Ubiquitin Ligase
por: Yoneyama, Yosuke, et al.
Publicado: (2018)

Role of FIP200 in cardiac and liver development and its regulation of TNFα and TSC–mTOR signaling pathways
por: Gan, Boyi, et al.
Publicado: (2006)

Ulk1, Not Ulk2, Is Required for Exercise Training-Induced Improvement of Insulin Response in Skeletal Muscle
por: Drake, Joshua C., et al.
Publicado: (2021)

The role of mammalian autophagy in protein metabolism
por: Mizushima, Noboru
Publicado: (2007)

Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation
por: Zhou, Zixuan, et al.
Publicado: (2021)

IQGAP1 Functions as a Modulator of Dishevelled Nuclear Localization in Wnt Signaling
por: Goto, Toshiyasu, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_2i0dqi4fumlkakr3gk496h1dd1