Cargando…

ATM polymorphisms as risk factors for prostate cancer development

The risk of prostate cancer is known to be elevated in carriers of germline mutations in BRCA2, and possibly also in carriers of BRCA1 and CHEK2 mutations. These genes are components of the ATM-dependent DNA damage signalling pathways. To evaluate the hypothesis that variants in ATM itself might be...

Descripción completa

Detalles Bibliográficos
Autores principales:	Angèle, S, Falconer, A, Edwards, S M, Dörk, T, Bremer, M, Moullan, N, Chapot, B, Muir, K, Houlston, R, Norman, A R, Bullock, S, Hope, Q, Meitz, J, Dearnaley, D, Dowe, A, Southgate, C, Ardern-Jones, A, Easton, D F, Eeles, R A, Hall, J
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2004
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364767/ https://www.ncbi.nlm.nih.gov/pubmed/15280931 http://dx.doi.org/10.1038/sj.bjc.6602007

Ejemplares similares

HPC2/ELAC2 polymorphisms and prostate cancer risk: analysis by age of onset of disease
por: Meitz, J C, et al.
Publicado: (2002)

Prostate cancer in BRCA2 germline mutation carriers is associated with poorer prognosis
por: Edwards, S M, et al.
Publicado: (2010)

No germline mutations in the dimerization domain of MXI1 in prostate cancer clusters. The CRC/BPG UK Familial Prostate Cancer Study Collaborators. Cancer Research Campaign/British Prostate Group.
por: Edwards, S. M., et al.
Publicado: (1997)

Allelic imbalance in familial and sporadic prostate cancer at the putative human prostate cancer susceptibility locus, HPC1. CRC/BPG UK Familial Prostate Cancer Study Collaborators. Cancer Research Campaign/British Prostate Group.
por: Dunsmuir, W. D., et al.
Publicado: (1998)

CHEK2 variants in susceptibility to breast cancer and evidence of retention of the wild type allele in tumours
por: Sodha, N, et al.
Publicado: (2002)

A recurrent truncating germline mutation in the BRIP1/FANCJ gene and susceptibility to prostate cancer
por: Kote-Jarai, Z, et al.
Publicado: (2009)

Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours
por: Reiman, A, et al.
Publicado: (2011)

Thymidylate synthase polymorphisms, folate and B-vitamin intake, and risk of colorectal adenoma
por: Hubner, R A, et al.
Publicado: (2007)

Mutation analysis of the MSMB gene in familial prostate cancer
por: Kote-Jarai, Z, et al.
Publicado: (2010)

The G67E mutation in hMLH1 is associated with an unusual presentation of Lynch syndrome
por: Clyne, M, et al.
Publicado: (2009)

Increased level of chromosomal damage after irradiation of lymphocytes from BRCA1 mutation carriers
por: Kote-Jarai, Z, et al.
Publicado: (2006)

Cellular responses to ionising radiation of AT heterozygotes: differences between missense and truncating mutation carriers
por: Fernet, M, et al.
Publicado: (2004)

Molecular variants of the ATM gene in Hodgkin's disease in children
por: Liberzon, E, et al.
Publicado: (2004)

ATM variants 7271T>G and IVS10-6T>G among women with unilateral and bilateral breast cancer
por: Bernstein, J L, et al.
Publicado: (2003)

ATM haplotypes and breast cancer risk in Jewish high-risk women
por: Koren, M, et al.
Publicado: (2006)

BRCA2 is a moderate penetrance gene contributing to young-onset prostate cancer: implications for genetic testing in prostate cancer patients
por: Kote-Jarai, Z, et al.
Publicado: (2011)

Prostate cancer in male BRCA1 and BRCA2 mutation carriers has a more aggressive phenotype
por: Mitra, A, et al.
Publicado: (2008)

Polygenic susceptibility to prostate and breast cancer: implications for personalised screening
por: Pashayan, N, et al.
Publicado: (2011)

Role of MC1R variants in uveal melanoma
por: Hearle, N, et al.
Publicado: (2003)

Diagnostic radiation procedures and risk of prostate cancer
por: Myles, P, et al.
Publicado: (2008)

Apoptosis, ageing and cancer susceptibility
por: Camplejohn, R S, et al.
Publicado: (2003)

Germline BRCA1 mutations increase prostate cancer risk
por: Leongamornlert, D, et al.
Publicado: (2012)

Construction of tissue microarrays from prostate needle biopsy specimens
por: Jhavar, S, et al.
Publicado: (2005)

Glutathione-S-transferase M1, T1 and P1 polymorphisms, and breast cancer risk, in BRCA1/2 mutation carriers
por: Kadouri, L, et al.
Publicado: (2008)

A single-nucleotide polymorphism in the RAD51 gene modifies breast cancer risk in BRCA2 carriers, but not in BRCA1 carriers or noncarriers
por: Kadouri, L, et al.
Publicado: (2004)

A physical analysis of the Y chromosome shows no additional deletions, other than Gr/Gr, associated with testicular germ cell tumour
por: Linger, R, et al.
Publicado: (2007)

Homeostatic nuclear RAGE–ATM interaction is essential for efficient DNA repair
por: Kumar, Varun, et al.
Publicado: (2017)

Search for inherited susceptibility to radiation-associated meningioma by genomewide SNP linkage disequilibrium mapping
por: Hosking, F J, et al.
Publicado: (2011)

MRE11 UFMylation promotes ATM activation
por: Wang, Zhifeng, et al.
Publicado: (2019)

Prognostic significance of folate metabolism polymorphisms for lung cancer
por: Matakidou, A, et al.
Publicado: (2007)

CASP8 variants D302H and −652 6N ins/del do not influence the risk of colorectal cancer in the United Kingdom population
por: Pittman, A M, et al.
Publicado: (2008)

Persistent DNA damage associated with ATM kinase deficiency promotes microglial dysfunction
por: Bourseguin, Julie, et al.
Publicado: (2022)

Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation
por: Bakr, A., et al.
Publicado: (2015)

Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas
por: Barker, K T, et al.
Publicado: (2002)

TGFBR1 variants TGFBR1(*)6A and Int7G24A are not associated with an increased familial colorectal cancer risk
por: Skoglund Lundin, J, et al.
Publicado: (2009)

HapMap-based study of the 17q21 ERBB2 amplicon in susceptibility to breast cancer
por: Benusiglio, P R, et al.
Publicado: (2006)

The BOADICEA model of genetic susceptibility to breast and ovarian cancer
por: Antoniou, A C, et al.
Publicado: (2004)

The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator
por: Jungmichel, Stephanie, et al.
Publicado: (2012)

Single-nucleotide polymorphisms in the RB1 gene and association with breast cancer in the British population
por: Lesueur, F, et al.
Publicado: (2006)

BRCA1 testing should be offered to individuals with triple-negative breast cancer diagnosed below 50 years
por: Robertson, L, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_tbc86ls0grkdgkn9bu5bu7aor7