Synthesis, Structure and Biological Activity of 6-R(3)Si(Ge, Sn)-Substituted 5-Fluorouracils

Direct lithiation of 1-(2-tetrahydrofuryl)-5-fluorouracil (Ftorafur) has been investigated. The treatment of ftorafur with lithium diisopropylamide (LDA)at –70℃ in ether-hexane, followed by the reaction with various electrophiles afforded the corresponding 6-substituted silicon, germanium and tin de...

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Detalles Bibliográficos
Autores principales: Lukevics, E., Ignatovich, L., Shilina, N., Kemme, A., Sjakste, N.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364875/
https://www.ncbi.nlm.nih.gov/pubmed/18476217
http://dx.doi.org/10.1155/MBD.1994.65
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author Lukevics, E.
Ignatovich, L.
Shilina, N.
Kemme, A.
Sjakste, N.
author_facet Lukevics, E.
Ignatovich, L.
Shilina, N.
Kemme, A.
Sjakste, N.
author_sort Lukevics, E.
collection PubMed
description Direct lithiation of 1-(2-tetrahydrofuryl)-5-fluorouracil (Ftorafur) has been investigated. The treatment of ftorafur with lithium diisopropylamide (LDA)at –70℃ in ether-hexane, followed by the reaction with various electrophiles afforded the corresponding 6-substituted silicon, germanium and tin derivatives of ftorafur. The results of biological investigation indicate the ability of germanium–modified nucleoside analogues to interfere with transcription and replication processes.
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spelling pubmed-23648752008-05-12 Synthesis, Structure and Biological Activity of 6-R(3)Si(Ge, Sn)-Substituted 5-Fluorouracils Lukevics, E. Ignatovich, L. Shilina, N. Kemme, A. Sjakste, N. Met Based Drugs Research Article Direct lithiation of 1-(2-tetrahydrofuryl)-5-fluorouracil (Ftorafur) has been investigated. The treatment of ftorafur with lithium diisopropylamide (LDA)at –70℃ in ether-hexane, followed by the reaction with various electrophiles afforded the corresponding 6-substituted silicon, germanium and tin derivatives of ftorafur. The results of biological investigation indicate the ability of germanium–modified nucleoside analogues to interfere with transcription and replication processes. Hindawi Publishing Corporation 1994 /pmc/articles/PMC2364875/ /pubmed/18476217 http://dx.doi.org/10.1155/MBD.1994.65 Text en Copyright © 1994 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lukevics, E.
Ignatovich, L.
Shilina, N.
Kemme, A.
Sjakste, N.
Synthesis, Structure and Biological Activity of 6-R(3)Si(Ge, Sn)-Substituted 5-Fluorouracils
title Synthesis, Structure and Biological Activity of 6-R(3)Si(Ge, Sn)-Substituted 5-Fluorouracils
title_full Synthesis, Structure and Biological Activity of 6-R(3)Si(Ge, Sn)-Substituted 5-Fluorouracils
title_fullStr Synthesis, Structure and Biological Activity of 6-R(3)Si(Ge, Sn)-Substituted 5-Fluorouracils
title_full_unstemmed Synthesis, Structure and Biological Activity of 6-R(3)Si(Ge, Sn)-Substituted 5-Fluorouracils
title_short Synthesis, Structure and Biological Activity of 6-R(3)Si(Ge, Sn)-Substituted 5-Fluorouracils
title_sort synthesis, structure and biological activity of 6-r(3)si(ge, sn)-substituted 5-fluorouracils
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364875/
https://www.ncbi.nlm.nih.gov/pubmed/18476217
http://dx.doi.org/10.1155/MBD.1994.65
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