2D NMR Methods for Structural Delineation of Copper(II) Complexes of Penicillin and Pilocarpine

A method was developed for delineating the structure of paramagnetic metal complexes. The selective disappearance of cross-peaks in proton-carbon shift correlated 2D NMR maps was shown to uniquely depend upon the scalar and/or dipolar interaction between ligand nuclei and the unpaired electron(s), t...

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Detalles Bibliográficos
Autores principales: Gaggelli, Elena, Gaggelli, Nicola, Valensin, Gianni
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364899/
https://www.ncbi.nlm.nih.gov/pubmed/18476239
http://dx.doi.org/10.1155/MBD.1994.279
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author Gaggelli, Elena
Gaggelli, Nicola
Valensin, Gianni
author_facet Gaggelli, Elena
Gaggelli, Nicola
Valensin, Gianni
author_sort Gaggelli, Elena
collection PubMed
description A method was developed for delineating the structure of paramagnetic metal complexes. The selective disappearance of cross-peaks in proton-carbon shift correlated 2D NMR maps was shown to uniquely depend upon the scalar and/or dipolar interaction between ligand nuclei and the unpaired electron(s), thus providing a means of identifying binding sites. Copper(II) was shown to form metal complexes with both Penicillin (PNC) and Pilocarpine (PLC) and the structure of the two 1:2 complexes in water solution at physiological pH were determined.
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spelling pubmed-23648992008-05-12 2D NMR Methods for Structural Delineation of Copper(II) Complexes of Penicillin and Pilocarpine Gaggelli, Elena Gaggelli, Nicola Valensin, Gianni Met Based Drugs Research Article A method was developed for delineating the structure of paramagnetic metal complexes. The selective disappearance of cross-peaks in proton-carbon shift correlated 2D NMR maps was shown to uniquely depend upon the scalar and/or dipolar interaction between ligand nuclei and the unpaired electron(s), thus providing a means of identifying binding sites. Copper(II) was shown to form metal complexes with both Penicillin (PNC) and Pilocarpine (PLC) and the structure of the two 1:2 complexes in water solution at physiological pH were determined. Hindawi Publishing Corporation 1994 /pmc/articles/PMC2364899/ /pubmed/18476239 http://dx.doi.org/10.1155/MBD.1994.279 Text en Copyright © 1994 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gaggelli, Elena
Gaggelli, Nicola
Valensin, Gianni
2D NMR Methods for Structural Delineation of Copper(II) Complexes of Penicillin and Pilocarpine
title 2D NMR Methods for Structural Delineation of Copper(II) Complexes of Penicillin and Pilocarpine
title_full 2D NMR Methods for Structural Delineation of Copper(II) Complexes of Penicillin and Pilocarpine
title_fullStr 2D NMR Methods for Structural Delineation of Copper(II) Complexes of Penicillin and Pilocarpine
title_full_unstemmed 2D NMR Methods for Structural Delineation of Copper(II) Complexes of Penicillin and Pilocarpine
title_short 2D NMR Methods for Structural Delineation of Copper(II) Complexes of Penicillin and Pilocarpine
title_sort 2d nmr methods for structural delineation of copper(ii) complexes of penicillin and pilocarpine
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364899/
https://www.ncbi.nlm.nih.gov/pubmed/18476239
http://dx.doi.org/10.1155/MBD.1994.279
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