Synthesis of 4-Amino-1-Hydroxy-Butane-1,1-Diphosphonate (AHBDP) - Stannous Complexes for the Preparation of Ahbdp-Sn(II)-Tc and its Biodistribution in Rats

The new potential tracer of bone imaging, AHBDP-Sn(II)-TcO.3H(2)O was synthesized by reducing the TcO(4)(−) to TcO(2)(+) in the presence of AHBDP and Sn(ll)’s reducing agent. We found that tin rapidly forms a stable complex with AHBDP, giving AHBDP-Sn(II).3H(2)O. In the excess of AHBDP-Sn(ll).3H(2)O...

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Detalles Bibliográficos
Autores principales: Mankhetkorn, Samlee, Blanchot, Caroline, Duran-Cordobes, Muriel, El Manouni, Driss, Leroux, Yves, Moretti, Jean-Luc
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364975/
https://www.ncbi.nlm.nih.gov/pubmed/18472767
http://dx.doi.org/10.1155/MBD.1995.201
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author Mankhetkorn, Samlee
Blanchot, Caroline
Duran-Cordobes, Muriel
El Manouni, Driss
Leroux, Yves
Moretti, Jean-Luc
author_facet Mankhetkorn, Samlee
Blanchot, Caroline
Duran-Cordobes, Muriel
El Manouni, Driss
Leroux, Yves
Moretti, Jean-Luc
author_sort Mankhetkorn, Samlee
collection PubMed
description The new potential tracer of bone imaging, AHBDP-Sn(II)-TcO.3H(2)O was synthesized by reducing the TcO(4)(−) to TcO(2)(+) in the presence of AHBDP and Sn(ll)’s reducing agent. We found that tin rapidly forms a stable complex with AHBDP, giving AHBDP-Sn(II).3H(2)O. In the excess of AHBDP-Sn(ll).3H(2)O, the AHBDP-Sn(II).3H(2)O coordinates with TcO(2)(+) to give AHBDP-Sn(II)-TcO.3H(2)O which could polymerise or oligomerise to give hydrophobic species. The overall process appears as a first-order reaction (K= 0.67 ± 0.005s(−1)). In rats, the fixation of AHBDP-Sn(II)-(99m)TcO. 3H(2)O on bone is homogeneous and the scintigraphic images have the same quality as those of 1-hydroxymethane-1,1-diphosphonate-Technetium (HMDP-(99m)Tc). The activity in non-target organs was neglible.
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spelling pubmed-23649752008-05-12 Synthesis of 4-Amino-1-Hydroxy-Butane-1,1-Diphosphonate (AHBDP) - Stannous Complexes for the Preparation of Ahbdp-Sn(II)-Tc and its Biodistribution in Rats Mankhetkorn, Samlee Blanchot, Caroline Duran-Cordobes, Muriel El Manouni, Driss Leroux, Yves Moretti, Jean-Luc Met Based Drugs Research Article The new potential tracer of bone imaging, AHBDP-Sn(II)-TcO.3H(2)O was synthesized by reducing the TcO(4)(−) to TcO(2)(+) in the presence of AHBDP and Sn(ll)’s reducing agent. We found that tin rapidly forms a stable complex with AHBDP, giving AHBDP-Sn(II).3H(2)O. In the excess of AHBDP-Sn(ll).3H(2)O, the AHBDP-Sn(II).3H(2)O coordinates with TcO(2)(+) to give AHBDP-Sn(II)-TcO.3H(2)O which could polymerise or oligomerise to give hydrophobic species. The overall process appears as a first-order reaction (K= 0.67 ± 0.005s(−1)). In rats, the fixation of AHBDP-Sn(II)-(99m)TcO. 3H(2)O on bone is homogeneous and the scintigraphic images have the same quality as those of 1-hydroxymethane-1,1-diphosphonate-Technetium (HMDP-(99m)Tc). The activity in non-target organs was neglible. Hindawi Publishing Corporation 1995 /pmc/articles/PMC2364975/ /pubmed/18472767 http://dx.doi.org/10.1155/MBD.1995.201 Text en Copyright © 1995 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mankhetkorn, Samlee
Blanchot, Caroline
Duran-Cordobes, Muriel
El Manouni, Driss
Leroux, Yves
Moretti, Jean-Luc
Synthesis of 4-Amino-1-Hydroxy-Butane-1,1-Diphosphonate (AHBDP) - Stannous Complexes for the Preparation of Ahbdp-Sn(II)-Tc and its Biodistribution in Rats
title Synthesis of 4-Amino-1-Hydroxy-Butane-1,1-Diphosphonate (AHBDP) - Stannous Complexes for the Preparation of Ahbdp-Sn(II)-Tc and its Biodistribution in Rats
title_full Synthesis of 4-Amino-1-Hydroxy-Butane-1,1-Diphosphonate (AHBDP) - Stannous Complexes for the Preparation of Ahbdp-Sn(II)-Tc and its Biodistribution in Rats
title_fullStr Synthesis of 4-Amino-1-Hydroxy-Butane-1,1-Diphosphonate (AHBDP) - Stannous Complexes for the Preparation of Ahbdp-Sn(II)-Tc and its Biodistribution in Rats
title_full_unstemmed Synthesis of 4-Amino-1-Hydroxy-Butane-1,1-Diphosphonate (AHBDP) - Stannous Complexes for the Preparation of Ahbdp-Sn(II)-Tc and its Biodistribution in Rats
title_short Synthesis of 4-Amino-1-Hydroxy-Butane-1,1-Diphosphonate (AHBDP) - Stannous Complexes for the Preparation of Ahbdp-Sn(II)-Tc and its Biodistribution in Rats
title_sort synthesis of 4-amino-1-hydroxy-butane-1,1-diphosphonate (ahbdp) - stannous complexes for the preparation of ahbdp-sn(ii)-tc and its biodistribution in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364975/
https://www.ncbi.nlm.nih.gov/pubmed/18472767
http://dx.doi.org/10.1155/MBD.1995.201
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