Steric Determinants of Pt/DNA Interactions and Anticancer Activity

Studies directed at establishing the structural features that control Pt/DNA interactions and the anticancer activity of Pt drugs are described. [(1)H, (15)N]-HSQC 2D NMR spectroscopic studies of the reactions of cisplatin with oligonucleotides containing ApG and GpA binding sites reveal dramatic di...

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Detalles Bibliográficos
Autores principales: Hambley, Trevor W., Berners-Price, Susan J., Davies, Murray S., Diakos, Connie I., Er, Hui Meng, Fenton, Ronald R., Ling, Edwina C. H., Rezler, Evonne M.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365127/
https://www.ncbi.nlm.nih.gov/pubmed/18475844
http://dx.doi.org/10.1155/MBD.1998.197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365127/
https://www.ncbi.nlm.nih.gov/pubmed/18475844
http://dx.doi.org/10.1155/MBD.1998.197

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