Antitumor Trans Platinum DNA Adducts: NMR and HPLC Study of the Interaction Between a trans-Pt Iminoether Complex and the Deoxy Decamer d(CCTCGCTCTC)·d(GAGAGCGAGG)

The single-stranded oligonucleotide 5′-d(CCTCGCTCTC) (I) was reacted with the antitumor trans platinum iminoderivative trans-[PtCl(2){E-HN = C(OMe)Me}(2)] (trans-EE) and subsequently annealed with its complementary strand 5′-d(GAGAGCGAGG) (II). The platinated duplex was characterized by 1D and 2D pr...

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Detalles Bibliográficos
Autores principales: Andersen, Bjørn, Margiotta, Nicola, Coluccia, Mauro, Natile, Giovanni, Sletten, Einar
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2000
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365194/
https://www.ncbi.nlm.nih.gov/pubmed/18475920
http://dx.doi.org/10.1155/MBD.2000.23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365194/
https://www.ncbi.nlm.nih.gov/pubmed/18475920
http://dx.doi.org/10.1155/MBD.2000.23

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