CD45RB Is a Novel Molecular Therapeutic Target to Inhibit Aβ Peptide-Induced Microglial MAPK Activation

BACKGROUND: Microglial activation, characterized by p38 MAPK or p44/42 MAPK pathway signal transduction, occurs in Alzheimer's disease (AD). Our previous studies demonstrated CD45, a membrane-bound protein tyrosine phosphatase (PTP), opposed β-amyloid (Aβ) peptide-induced microglial activation...

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Detalles Bibliográficos
Autores principales: Zhu, Yuyan, Hou, Huayan, Nikolic, William V., Ehrhart, Jared, Rrapo, Elona, Bickford, Paula, Giunta, Brian, Tan, Jun
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366070/
https://www.ncbi.nlm.nih.gov/pubmed/18478117
http://dx.doi.org/10.1371/journal.pone.0002135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366070/
https://www.ncbi.nlm.nih.gov/pubmed/18478117
http://dx.doi.org/10.1371/journal.pone.0002135

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