Antioxidant and Prooxidant Effects of Metal Dafonates on the NADPH-Dependent Lipid Peroxidation in the Murine Hepatic Microsomal System

Dafone inhibits the lipid peroxidation significantly in a concentration dependent manner. The inhibition was found to be an uncompetitive type with the inhibition constant (Ki) of 62.5μM On the other hand complexation with metal ions results in a significant reversal from antioxidant to pro-oxidant...

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Detalles Bibliográficos
Autores principales: Gupta, M., Kale, R. K., Kulkarni, P. P., Padhye, S. B.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1999
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366826/
https://www.ncbi.nlm.nih.gov/pubmed/18472908
http://dx.doi.org/10.1155/MBD.1999.169
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author Gupta, M.
Kale, R. K.
Kulkarni, P. P.
Padhye, S. B.
author_facet Gupta, M.
Kale, R. K.
Kulkarni, P. P.
Padhye, S. B.
author_sort Gupta, M.
collection PubMed
description Dafone inhibits the lipid peroxidation significantly in a concentration dependent manner. The inhibition was found to be an uncompetitive type with the inhibition constant (Ki) of 62.5μM On the other hand complexation with metal ions results in a significant reversal from antioxidant to pro-oxidant properties for the resulting complexes which are cationic and with associated halometallate anions. The nature of the potentiation in case of the ferric compound was of competitive type with activation constant (Ka) having the value 32.5μM. The neutral copper-dafonate complex, however, inhibits lipid peroxidation with increase in concentration.
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spelling pubmed-23668262008-05-12 Antioxidant and Prooxidant Effects of Metal Dafonates on the NADPH-Dependent Lipid Peroxidation in the Murine Hepatic Microsomal System Gupta, M. Kale, R. K. Kulkarni, P. P. Padhye, S. B. Met Based Drugs Research Article Dafone inhibits the lipid peroxidation significantly in a concentration dependent manner. The inhibition was found to be an uncompetitive type with the inhibition constant (Ki) of 62.5μM On the other hand complexation with metal ions results in a significant reversal from antioxidant to pro-oxidant properties for the resulting complexes which are cationic and with associated halometallate anions. The nature of the potentiation in case of the ferric compound was of competitive type with activation constant (Ka) having the value 32.5μM. The neutral copper-dafonate complex, however, inhibits lipid peroxidation with increase in concentration. Hindawi Publishing Corporation 1999 /pmc/articles/PMC2366826/ /pubmed/18472908 http://dx.doi.org/10.1155/MBD.1999.169 Text en Copyright © 1999 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gupta, M.
Kale, R. K.
Kulkarni, P. P.
Padhye, S. B.
Antioxidant and Prooxidant Effects of Metal Dafonates on the NADPH-Dependent Lipid Peroxidation in the Murine Hepatic Microsomal System
title Antioxidant and Prooxidant Effects of Metal Dafonates on the NADPH-Dependent Lipid Peroxidation in the Murine Hepatic Microsomal System
title_full Antioxidant and Prooxidant Effects of Metal Dafonates on the NADPH-Dependent Lipid Peroxidation in the Murine Hepatic Microsomal System
title_fullStr Antioxidant and Prooxidant Effects of Metal Dafonates on the NADPH-Dependent Lipid Peroxidation in the Murine Hepatic Microsomal System
title_full_unstemmed Antioxidant and Prooxidant Effects of Metal Dafonates on the NADPH-Dependent Lipid Peroxidation in the Murine Hepatic Microsomal System
title_short Antioxidant and Prooxidant Effects of Metal Dafonates on the NADPH-Dependent Lipid Peroxidation in the Murine Hepatic Microsomal System
title_sort antioxidant and prooxidant effects of metal dafonates on the nadph-dependent lipid peroxidation in the murine hepatic microsomal system
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366826/
https://www.ncbi.nlm.nih.gov/pubmed/18472908
http://dx.doi.org/10.1155/MBD.1999.169
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AT kulkarnipp antioxidantandprooxidanteffectsofmetaldafonatesonthenadphdependentlipidperoxidationinthemurinehepaticmicrosomalsystem
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