Genetic heterogeneity and trans regulators of gene expression

Heterogeneity poses a challenge to linkage mapping. Here, we apply a latent class extension of Haseman-Elston regression to expression phenotypes with significant evidence of linkage to trans regulators in 14 large pedigrees. We test for linkage, accounting for heterogeneity, and classify individual...

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Detalles Bibliográficos
Autores principales: Bastone, Laurel A, Putt, Mary E, Ten Have, Thomas R, Cheung, Vivian G, Spielman, Richard S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367595/
https://www.ncbi.nlm.nih.gov/pubmed/18466583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367595/
https://www.ncbi.nlm.nih.gov/pubmed/18466583

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