Genetic heterogeneity and trans regulators of gene expression

Heterogeneity poses a challenge to linkage mapping. Here, we apply a latent class extension of Haseman-Elston regression to expression phenotypes with significant evidence of linkage to trans regulators in 14 large pedigrees. We test for linkage, accounting for heterogeneity, and classify individual...

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Detalles Bibliográficos
Autores principales: Bastone, Laurel A, Putt, Mary E, Ten Have, Thomas R, Cheung, Vivian G, Spielman, Richard S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367595/
https://www.ncbi.nlm.nih.gov/pubmed/18466583
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author Bastone, Laurel A
Putt, Mary E
Ten Have, Thomas R
Cheung, Vivian G
Spielman, Richard S
author_facet Bastone, Laurel A
Putt, Mary E
Ten Have, Thomas R
Cheung, Vivian G
Spielman, Richard S
author_sort Bastone, Laurel A
collection PubMed
description Heterogeneity poses a challenge to linkage mapping. Here, we apply a latent class extension of Haseman-Elston regression to expression phenotypes with significant evidence of linkage to trans regulators in 14 large pedigrees. We test for linkage, accounting for heterogeneity, and classify individual families as "linked" and "unlinked" on the basis of their contribution to the overall evidence of linkage.
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spelling pubmed-23675952008-05-06 Genetic heterogeneity and trans regulators of gene expression Bastone, Laurel A Putt, Mary E Ten Have, Thomas R Cheung, Vivian G Spielman, Richard S BMC Proc Proceedings Heterogeneity poses a challenge to linkage mapping. Here, we apply a latent class extension of Haseman-Elston regression to expression phenotypes with significant evidence of linkage to trans regulators in 14 large pedigrees. We test for linkage, accounting for heterogeneity, and classify individual families as "linked" and "unlinked" on the basis of their contribution to the overall evidence of linkage. BioMed Central 2007-12-18 /pmc/articles/PMC2367595/ /pubmed/18466583 Text en Copyright © 2007 Bastone et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Bastone, Laurel A
Putt, Mary E
Ten Have, Thomas R
Cheung, Vivian G
Spielman, Richard S
Genetic heterogeneity and trans regulators of gene expression
title Genetic heterogeneity and trans regulators of gene expression
title_full Genetic heterogeneity and trans regulators of gene expression
title_fullStr Genetic heterogeneity and trans regulators of gene expression
title_full_unstemmed Genetic heterogeneity and trans regulators of gene expression
title_short Genetic heterogeneity and trans regulators of gene expression
title_sort genetic heterogeneity and trans regulators of gene expression
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367595/
https://www.ncbi.nlm.nih.gov/pubmed/18466583
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AT tenhavethomasr geneticheterogeneityandtransregulatorsofgeneexpression
AT cheungviviang geneticheterogeneityandtransregulatorsofgeneexpression
AT spielmanrichards geneticheterogeneityandtransregulatorsofgeneexpression

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