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Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences
Meganucleases cut long (>12 bp) unique sequences in genomes and can be used to induce targeted genome engineering by homologous recombination in the vicinity of their cleavage site. However, the use of natural meganucleases is limited by the repertoire of their target sequences, and considerable...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367722/ https://www.ncbi.nlm.nih.gov/pubmed/18276641 http://dx.doi.org/10.1093/nar/gkn059 |