Single-molecule observations of topotecan-mediated TopIB activity at a unique DNA sequence

The rate of DNA supercoil removal by human topoisomerase IB (TopIB) is slowed down by the presence of the camptothecin class of antitumor drugs. By preventing religation, these drugs also prolong the lifetime of the covalent TopIB–DNA complex. Here, we use magnetic tweezers to measure the rate of su...

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Detalles Bibliográficos
Autores principales: Koster, Daniel A., Czerwinski, Fabian, Halby, Ludovic, Crut, Aurélien, Vekhoff, Pierre, Palle, Komaraiah, Arimondo, Paola B., Dekker, Nynke H.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367732/
https://www.ncbi.nlm.nih.gov/pubmed/18292117
http://dx.doi.org/10.1093/nar/gkn035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367732/
https://www.ncbi.nlm.nih.gov/pubmed/18292117
http://dx.doi.org/10.1093/nar/gkn035

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