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Gpnmb(R150X )allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma
BACKGROUND: The Gpnmb gene encodes a transmembrane protein whose function(s) remain largely unknown. Here, we assess if a mutant allele of Gpnmb confers susceptibility to glaucoma by altering immune functions. DBA/2J mice have a mutant Gpnmb gene and they develop a form of glaucoma preceded by a pig...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373794/ https://www.ncbi.nlm.nih.gov/pubmed/18402690 http://dx.doi.org/10.1186/1471-2156-9-30 |