The equilibrium and kinetic drug binding properties of the mouse P-gp1a and P-gp1b P-glycoproteins are similar

The gene encoding the multidrug resistance P-glycoprotein (P-gp) is duplicated in rodent species and the functional basis for this remains unresolved. Despite a high sequence similarity, the mouse P-gp1a and P-gp1b isoforms show distinct patterns of tissue distribution which suggest a specific role...

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Detalles Bibliográficos
Autores principales: Taylor, J C, Ferry, D R, Higgins, C F, Callaghan, R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374293/
https://www.ncbi.nlm.nih.gov/pubmed/10555746
http://dx.doi.org/10.1038/sj.bjc.6690764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374293/
https://www.ncbi.nlm.nih.gov/pubmed/10555746
http://dx.doi.org/10.1038/sj.bjc.6690764

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