Dipyridamole potentiates the in vitro activity of MTA (LY231514) by inhibition of thymidine transport

The novel pyrrolopyrimidine-based antifolate LY231514 (MTA), inhibits multiple folate-requiring enzymes including thymidylate synthase, glycinamide ribonucleotide formyltransferase and dihydrofolate reductase. Both thymidine and hypoxanthine are required to reverse MTA growth inhibition in leukaemia...

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Detalles Bibliográficos
Autores principales: Smith, P G, Marshman, E, Newell, D R, Curtin, N J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374405/
https://www.ncbi.nlm.nih.gov/pubmed/10732767
http://dx.doi.org/10.1054/bjoc.1999.1020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374405/
https://www.ncbi.nlm.nih.gov/pubmed/10732767
http://dx.doi.org/10.1054/bjoc.1999.1020

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