Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis

INTRODUCTION: CP-690550 is a small molecule inhibitor of Janus kinase 3 (JAK3), a critical enzyme in the signaling pathway of multiple cytokines (interleukin (IL)-2, -7, -15 and -21) that are important in various T cell functions including development, activation and homeostasis. The purpose of this...

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Detalles Bibliográficos
Autores principales: Milici, Anthony J, Kudlacz, Elizabeth M, Audoly, Laurent, Zwillich, Samuel, Changelian, Paul
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374467/
https://www.ncbi.nlm.nih.gov/pubmed/18234077
http://dx.doi.org/10.1186/ar2365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374467/
https://www.ncbi.nlm.nih.gov/pubmed/18234077
http://dx.doi.org/10.1186/ar2365

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