Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells

We show here that mitoxantrone and ametantrone induce interstrand DNA cross-links in HeLa S(3)cells. These cross-links were observed only in cellular system suggesting that metabolism of the drugs is a necessary step leading to DNA cross-linking. Biologically inactive analogue of mitoxantrone, compo...

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Detalles Bibliográficos
Autores principales: Skladanowski, A, Konopa, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374491/
https://www.ncbi.nlm.nih.gov/pubmed/10755405
http://dx.doi.org/10.1054/bjoc.1999.1095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374491/
https://www.ncbi.nlm.nih.gov/pubmed/10755405
http://dx.doi.org/10.1054/bjoc.1999.1095

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