Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells

We show here that mitoxantrone and ametantrone induce interstrand DNA cross-links in HeLa S(3)cells. These cross-links were observed only in cellular system suggesting that metabolism of the drugs is a necessary step leading to DNA cross-linking. Biologically inactive analogue of mitoxantrone, compo...

Descripción completa

Detalles Bibliográficos
Autores principales: Skladanowski, A, Konopa, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374491/
https://www.ncbi.nlm.nih.gov/pubmed/10755405
http://dx.doi.org/10.1054/bjoc.1999.1095
_version_ 1782154466214019072
author Skladanowski, A
Konopa, J
author_facet Skladanowski, A
Konopa, J
author_sort Skladanowski, A
collection PubMed
description We show here that mitoxantrone and ametantrone induce interstrand DNA cross-links in HeLa S(3)cells. These cross-links were observed only in cellular system suggesting that metabolism of the drugs is a necessary step leading to DNA cross-linking. Biologically inactive analogue of mitoxantrone, compound NSC 321458, did not induce cross-links in DNA of tumour cells which suggests that DNA cross-linking is associated with the cytotoxic and anti-tumour activity of these compounds. © 2000 Cancer Research Campaign
format Text
id pubmed-2374491
institution National Center for Biotechnology Information
language English
publishDate 2000
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23744912009-09-10 Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells Skladanowski, A Konopa, J Br J Cancer Regular Article We show here that mitoxantrone and ametantrone induce interstrand DNA cross-links in HeLa S(3)cells. These cross-links were observed only in cellular system suggesting that metabolism of the drugs is a necessary step leading to DNA cross-linking. Biologically inactive analogue of mitoxantrone, compound NSC 321458, did not induce cross-links in DNA of tumour cells which suggests that DNA cross-linking is associated with the cytotoxic and anti-tumour activity of these compounds. © 2000 Cancer Research Campaign Nature Publishing Group 2000-04 2000-03-06 /pmc/articles/PMC2374491/ /pubmed/10755405 http://dx.doi.org/10.1054/bjoc.1999.1095 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Skladanowski, A
Konopa, J
Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells
title Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells
title_full Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells
title_fullStr Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells
title_full_unstemmed Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells
title_short Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells
title_sort mitoxantrone and ametantrone induce interstrand cross-links in dna of tumour cells
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374491/
https://www.ncbi.nlm.nih.gov/pubmed/10755405
http://dx.doi.org/10.1054/bjoc.1999.1095
work_keys_str_mv AT skladanowskia mitoxantroneandametantroneinduceinterstrandcrosslinksindnaoftumourcells
AT konopaj mitoxantroneandametantroneinduceinterstrandcrosslinksindnaoftumourcells

Ejemplares similares