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Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells
We show here that mitoxantrone and ametantrone induce interstrand DNA cross-links in HeLa S(3)cells. These cross-links were observed only in cellular system suggesting that metabolism of the drugs is a necessary step leading to DNA cross-linking. Biologically inactive analogue of mitoxantrone, compo...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2000
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374491/ https://www.ncbi.nlm.nih.gov/pubmed/10755405 http://dx.doi.org/10.1054/bjoc.1999.1095 |