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Concentrations of tamoxifen and its major metabolites in hormone responsive and resistant breast tumours
Patients treated with tamoxifen (TAM) for primary breast cancer often manifest de novo or acquired resistance, possibly through changes in drug metabolism. Using solid-phase extraction methods and reversed-phase high-performance liquid chromatography separations, levels of TAM and metabolites 4-hydr...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2000
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374506/ https://www.ncbi.nlm.nih.gov/pubmed/10817496 http://dx.doi.org/10.1054/bjoc.2000.1120 |