Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption

The causes for the propensity of metastasized prostate cancer cells to grow in bone and to induce osteoblastic lesions remain unresolved. Co-culture of human prostate cancer cell lines with bone slices was determined to increase the level of endothelin-1 (ET-1) mRNA and its production. ET-1 is an ej...

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Autores principales: Chiao, J W, Moonga, B S, Yang, Y M, Kancherla, R, Mittelman, A, Wu-Wong, J R, Ahmed, T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374574/
https://www.ncbi.nlm.nih.gov/pubmed/10917552
http://dx.doi.org/10.1054/bjoc.2000.1261
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author Chiao, J W
Moonga, B S
Yang, Y M
Kancherla, R
Mittelman, A
Wu-Wong, J R
Ahmed, T
author_facet Chiao, J W
Moonga, B S
Yang, Y M
Kancherla, R
Mittelman, A
Wu-Wong, J R
Ahmed, T
author_sort Chiao, J W
collection PubMed
description The causes for the propensity of metastasized prostate cancer cells to grow in bone and to induce osteoblastic lesions remain unresolved. Co-culture of human prostate cancer cell lines with bone slices was determined to increase the level of endothelin-1 (ET-1) mRNA and its production. ET-1 is an ejaculate protein that also stimulates osteoblasts. Osteoclastic bone resorption was significantly blocked by the presence of androgen-independent prostate cancer cells in a dose-dependent manner as that of synthetic ET-1. The inhibition could be neutralized by specific ET-1 antibody, indicating the association of prostate cancer-derived ET-1 with inhibition of bone resorption. The combined ET-1 activity on osteoclasts and osteoblasts disrupts bone remodelling. ET-1 production is also elevated in the presence of prostate-specific antigen (PSA). ET-1 in turn enhances DNA synthesis of prostate cancer cells. Interactions among cancer cells, bone, ET-1 and PSA may be critical in cancer growth and lesions in bone. © 2000 Cancer Research Campaign
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spelling pubmed-23745742009-09-10 Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption Chiao, J W Moonga, B S Yang, Y M Kancherla, R Mittelman, A Wu-Wong, J R Ahmed, T Br J Cancer Regular Article The causes for the propensity of metastasized prostate cancer cells to grow in bone and to induce osteoblastic lesions remain unresolved. Co-culture of human prostate cancer cell lines with bone slices was determined to increase the level of endothelin-1 (ET-1) mRNA and its production. ET-1 is an ejaculate protein that also stimulates osteoblasts. Osteoclastic bone resorption was significantly blocked by the presence of androgen-independent prostate cancer cells in a dose-dependent manner as that of synthetic ET-1. The inhibition could be neutralized by specific ET-1 antibody, indicating the association of prostate cancer-derived ET-1 with inhibition of bone resorption. The combined ET-1 activity on osteoclasts and osteoblasts disrupts bone remodelling. ET-1 production is also elevated in the presence of prostate-specific antigen (PSA). ET-1 in turn enhances DNA synthesis of prostate cancer cells. Interactions among cancer cells, bone, ET-1 and PSA may be critical in cancer growth and lesions in bone. © 2000 Cancer Research Campaign Nature Publishing Group 2000-07 2000-07-03 /pmc/articles/PMC2374574/ /pubmed/10917552 http://dx.doi.org/10.1054/bjoc.2000.1261 Text en Copyright © 2000 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Chiao, J W
Moonga, B S
Yang, Y M
Kancherla, R
Mittelman, A
Wu-Wong, J R
Ahmed, T
Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption
title Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption
title_full Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption
title_fullStr Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption
title_full_unstemmed Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption
title_short Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption
title_sort endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374574/
https://www.ncbi.nlm.nih.gov/pubmed/10917552
http://dx.doi.org/10.1054/bjoc.2000.1261
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