MDR 1 activation is the predominant resistance mechanism selected by vinblastine in MES-SA cells

Single-step selection with vinblastine was performed in populations of the human sarcoma cell line MES-SA, to assess cellular mechanisms of resistance to the drug and mutation rates via fluctuation analysis. At a stringent selection with 20 nM vinblastine, resulting in 5–6 logs of cell killing, the...

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Detalles Bibliográficos
Autores principales: Chen, G K, Durán, G E, Mangili, A, Beketic-Oreskovic, L, Sikic, B I
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374671/
https://www.ncbi.nlm.nih.gov/pubmed/10970691
http://dx.doi.org/10.1054/bjoc.2000.1371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374671/
https://www.ncbi.nlm.nih.gov/pubmed/10970691
http://dx.doi.org/10.1054/bjoc.2000.1371

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