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MDR 1 activation is the predominant resistance mechanism selected by vinblastine in MES-SA cells
Single-step selection with vinblastine was performed in populations of the human sarcoma cell line MES-SA, to assess cellular mechanisms of resistance to the drug and mutation rates via fluctuation analysis. At a stringent selection with 20 nM vinblastine, resulting in 5–6 logs of cell killing, the...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2000
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374671/ https://www.ncbi.nlm.nih.gov/pubmed/10970691 http://dx.doi.org/10.1054/bjoc.2000.1371 |