Pulmonary availability of isotretinoin in rats after inhalation of a powder aerosol

Repeated oral administration of chemopreventive retinoids such as isotretinoin over extended periods of time is associated with intolerable systemic toxicity. Here isotretinoin was formulated as a powder aerosol, and its delivery to the lungs of rats was studied with the aim to explore the possibili...

Descripción completa

Detalles Bibliográficos
Autores principales: Raleigh, S M, Verschoyle, R D, Bowskill, C, Pastorino, U, Staniforth, J N, Steele, F, Dinsdale, D, Carthew, P, Lim, C K, Silvester, J, Gescher, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2000
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374686/
https://www.ncbi.nlm.nih.gov/pubmed/10970697
http://dx.doi.org/10.1054/bjoc.2000.1421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374686/
https://www.ncbi.nlm.nih.gov/pubmed/10970697
http://dx.doi.org/10.1054/bjoc.2000.1421

Ejemplares similares