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Pulmonary availability of isotretinoin in rats after inhalation of a powder aerosol
Repeated oral administration of chemopreventive retinoids such as isotretinoin over extended periods of time is associated with intolerable systemic toxicity. Here isotretinoin was formulated as a powder aerosol, and its delivery to the lungs of rats was studied with the aim to explore the possibili...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2000
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374686/ https://www.ncbi.nlm.nih.gov/pubmed/10970697 http://dx.doi.org/10.1054/bjoc.2000.1421 |