Ubiquitin E3 Ligase Ring1b/Rnf2 of Polycomb Repressive Complex 1 Contributes to Stable Maintenance of Mouse Embryonic Stem Cells

BACKGROUND: Polycomb repressive complex 1 (PRC1) core member Ring1b/Rnf2, with ubiquitin E3 ligase activity towards histone H2A at lysine 119, is essential for early embryogenesis. To obtain more insight into the role of Ring1b in early development, we studied its function in mouse embryonic stem (E...

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Detalles Bibliográficos
Autores principales: van der Stoop, Petra, Boutsma, Erwin A., Hulsman, Danielle, Noback, Sonja, Heimerikx, Mike, Kerkhoven, Ron M., Voncken, J. Willem, Wessels, Lodewyk F. A., van Lohuizen, Maarten
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375055/
https://www.ncbi.nlm.nih.gov/pubmed/18493325
http://dx.doi.org/10.1371/journal.pone.0002235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375055/
https://www.ncbi.nlm.nih.gov/pubmed/18493325
http://dx.doi.org/10.1371/journal.pone.0002235

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