DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: role of telomere repeat binding factor 2

Treatment of colon cancer cells with MNNG causes DNA damage with reduced telomeric signals in a p53-dependent manner, but increased cell cycle arrest in S-G(2)/M by both p53-dependent and independent mechanisms. Results also indicate that cellular levels of TRF2 may play a critical role in MNNG-indu...

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Detalles Bibliográficos
Autores principales: Narayan, S, Jaiswal, A S, Multani, A S, Pathak, S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375064/
https://www.ncbi.nlm.nih.gov/pubmed/11556843
http://dx.doi.org/10.1054/bjoc.2001.2002
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author Narayan, S
Jaiswal, A S
Multani, A S
Pathak, S
author_facet Narayan, S
Jaiswal, A S
Multani, A S
Pathak, S
author_sort Narayan, S
collection PubMed
description Treatment of colon cancer cells with MNNG causes DNA damage with reduced telomeric signals in a p53-dependent manner, but increased cell cycle arrest in S-G(2)/M by both p53-dependent and independent mechanisms. Results also indicate that cellular levels of TRF2 may play a critical role in MNNG-induced cell cycle arrest and apoptosis of colon cancer cells. © 2001 Cancer Research Campaign http://www.bjcancer.com
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spelling pubmed-23750642009-09-10 DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: role of telomere repeat binding factor 2 Narayan, S Jaiswal, A S Multani, A S Pathak, S Br J Cancer Short Communication Treatment of colon cancer cells with MNNG causes DNA damage with reduced telomeric signals in a p53-dependent manner, but increased cell cycle arrest in S-G(2)/M by both p53-dependent and independent mechanisms. Results also indicate that cellular levels of TRF2 may play a critical role in MNNG-induced cell cycle arrest and apoptosis of colon cancer cells. © 2001 Cancer Research Campaign http://www.bjcancer.com Nature Publishing Group 2001-09 /pmc/articles/PMC2375064/ /pubmed/11556843 http://dx.doi.org/10.1054/bjoc.2001.2002 Text en Copyright © 2001 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Narayan, S
Jaiswal, A S
Multani, A S
Pathak, S
DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: role of telomere repeat binding factor 2
title DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: role of telomere repeat binding factor 2
title_full DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: role of telomere repeat binding factor 2
title_fullStr DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: role of telomere repeat binding factor 2
title_full_unstemmed DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: role of telomere repeat binding factor 2
title_short DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: role of telomere repeat binding factor 2
title_sort dna damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: role of telomere repeat binding factor 2
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375064/
https://www.ncbi.nlm.nih.gov/pubmed/11556843
http://dx.doi.org/10.1054/bjoc.2001.2002
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