Inactivation of wild-type p53 by a dominant negative mutant renders MCF-7 cells resistant to tubulin-binding agent cytotoxicity

The present study was performed to gain insight into the role of p53 on the cytotoxicity of tubulin-binding agents (TBA) on cancer cells. Drug sensitivity, cell cycle distribution and drug-induced apoptosis were compared in 2 lines derived from the mammary adenocarcinoma MCF-7: the MN-1 cell line co...

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Detalles Bibliográficos
Autores principales: Galmarini, C M, Falette, N, Tabone, E, Levrat, C, Britten, R, Voorzanger-Rousselot, N, Roesch-Gateau, O, Vanier-Viornery, A, Puisieux, A, Dumontet, C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375065/
https://www.ncbi.nlm.nih.gov/pubmed/11556844
http://dx.doi.org/10.1054/bjoc.2001.2017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375065/
https://www.ncbi.nlm.nih.gov/pubmed/11556844
http://dx.doi.org/10.1054/bjoc.2001.2017

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