Hypermethylation of CpG islands in the mouse asparagine synthetase gene: relationship to asparaginase sensitivity in lymphoma cells. Partial methylation in normal cells

We have sequenced the promoter region of the murine asparagine synthetase gene and examined its methylation profile in the CpG islands of L-asparaginase-sensitive 6C3HED cells (asparagine auxotrophs) and resistant variants (prototrophs). In the former, complete methylation of the CpG island is corre...

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Detalles Bibliográficos
Autores principales: Peng, H, Shen, N, Qian, L, Sun, X-L, Koduru, P, Goodwin, L O, Issa, J-P, Broome, J D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2001
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375082/
https://www.ncbi.nlm.nih.gov/pubmed/11556848
http://dx.doi.org/10.1054/bjoc.2001.2000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375082/
https://www.ncbi.nlm.nih.gov/pubmed/11556848
http://dx.doi.org/10.1054/bjoc.2001.2000

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