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Targeted Deficiency of the Transcriptional Activator Hnf1α Alters Subnuclear Positioning of Its Genomic Targets

DNA binding transcriptional activators play a central role in gene-selective regulation. In part, this is mediated by targeting local covalent modifications of histone tails. Transcriptional regulation has also been associated with the positioning of genes within the nucleus. We have now examined th...

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Detalles Bibliográficos
Autores principales: Luco, Reini F., Maestro, Miguel A., Sadoni, Nicolas, Zink, Daniele, Ferrer, Jorge
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375116/
https://www.ncbi.nlm.nih.gov/pubmed/18497863
http://dx.doi.org/10.1371/journal.pgen.1000079